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Although trial data in individuals aged younger than 60 years are lacking, it seems reasonable to recommend the systolic treatment threshold established in two trials of isolated systolic hypertension in the elderly, 66 131 namely a systolic BP persistently raised above 160 mm Hg.

The management of individuals in whom diastolic BP remains between 90 and 99 mm Hg and/or systolic BP between 140 and 159 mm Hg on repeated measurements should be considered in the context of their absolute risk of CHD and stroke, not CHD alone. 124 132 Nike Mens Sf Air Force 1 Mid Sneaker Gp9poqIoW
Risk of CHD and stroke increases across this BP range, but the scale of the risk for BP alone and hence potential benefit of drug treatment is relatively small. 128 Mephisto Womens Laser Walking Shoe mgywdGlMOy
However, the risk of hypertension is greatly increased when complicated by pre-existing target organ damage or the presence of other cardiovascular risk factors. Treatment decreases the risk and the absolute risk reduction is greater than in treating uncomplicated individuals, although the level of risk attained remains increased. 135 Consequently, in patients with target organ damage (LVH, retinopathy—haemorrhages or exudates—renal impairment or proteinuria, for example) or if they have other cardiovascular risk factors antihypertensive treatment is indicated.

On the basis of clinical trial data several national and international guidelines on hypertension management have been produced in recent years. Office HALLIE Wedge sandals fuchsia TOc2DVkQKv
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These guidelines are mainly, although not totally, in agreement over the management of BP. The only national guidelines which deviate from a management policy based primarily on BP levels are those from New Zealand. Stella McCartney Elyse metallic lace up shoes BAngaXCY26
These were the first to recommend a management policy based on BP levels assessed in the context of absolute cardiovascular risk, including stroke. In New Zealand a risk of 20% or higher of cardiovascular events over 10 years is considered acceptable for drug treatment since benefits are likely to exceed drug related adverse effects.

In the management of hypertension, such an approach is logical for the prevention of CHD. Individuals with a sustained diastolic BP of 100 mm Hg or greater, and/or systolic BP over 160 mm Hg, should be prescribed antihypertensive drugs because of established benefit in reducing total cardiovascular risk, and stroke in particular. In those with lower levels of sustained diastolic or systolic BP, 10 year cardiovascular (CHD and stroke) risk should be calculated (see appendix). It is important to calculate cardiovascular, and not just CHD, risk in the management of hypertension because of the additional benefit of BP lowering in relation to stroke. An absolute cardiovascular risk of 20% over 10 years is equivalent to an absolute CHD risk of 15% over the same time and this is the recommended threshold for antihypertensive drug treatment (fig DRKSHDW BY RICK OWENS Woman Canvas Sneakers Size 39 Qe0Yi
). Relative risk reduction with antihypertensive treatment is 16% and this is lower than the 33% attained by statin treatment. So the number of patients requiring treatment with antihypertensive drugs over a defined period at this level of absolute CHD risk, in order to prevent one major coronary event, will be larger than the number requiring cholesterol lowering therapy over the same period for the same benefit, although antihypertensive therapy will have a greater effect in reducing stroke events.

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Targeting your email

On the second create page you can target your email to your entire list, or a specific subset of your list.

First, choose the email list you'd like to send to from the drop down menu at the top. Your choices will be your personal email list (which includes all of the activists you collected through forms you created and/or your referral codes) and any group email lists that you are an administrator of. (Groups are explained more .)

Choosing a list targets your email to that entire list. You then have the option of cutting down your targeted universe further by including or excluding different sets of activists on your list below.

Standard Mode and Query Mode

In standard mode you have many options for targeting your list further and each appears as either an include or an exclude, which will include or exclude that set of activists from this email respectively.

You can also target with query mode, activated with the query mode toggle on top of the page. When in query mode you can target using the same filters as standard mode, but you get to choose the logical ANDs and ORs that go between each filter, allowing you to do more complex targeting. This mode uses the same options as our query feature. adidas Adilette Pride Slides Gr UK 7 zEeze

In query mode, you have the option to import existing saved queries to your current targeting. Select a query from the import query section and click "Import" to add that saved query's parameters at the end of your current query.

You can switch between query mode and standard mode at any time, though switching between them will clear any targeting currently on your email. Once the email is saved, it will always load its targeting in that mode unless switched. You can choose which mode is the default for you when making new emails or reports by editing your profile, as explained here .

Targeting Filters

You can target activists based on geography -- whether they live in one or many states, one or many US counties, one or many legislative districts (congress or state level), one or many countries, whether they live within a certain number of miles of a ZIP/postal code (or ZIP/postal codes, enter multiple separated by commas), or if you're sending to a group's list, whether they live within a certain number of miles of events that are part of a specific event campaign. (Event campaigns are explained more .)

You can target activists based on their preferred language.

You can target activists based on the email list of child groups they are on if the group is part of a network. For example, you can email activists on your group's list who are not on a child group's list. (Networks are explained more .)

You can target activists who live in places with targets on a certain letter campaign. For example, if you've set up a letter campaign targeting Representatives John and Jane Doe, you can choose that letter campaign as a target and only send your email to activists on your list who live in those Representatives' districts, ensuring that when your activists go to write a letter they won't see a "No targets found for your address" message.

You can target activists based on action or email history -- if they've taken action on one or multiple pages (including actions made by child groups if this group is part of a network, explained more ), if they are targeted by one or multiple emails you've made in the past, or if they've opened or clicked emails you've sent in the past.

You can target activists based on donation history -- all donors, active recurring donors, donors with failing recurring donations, donors with cancelled recurring donations, donors eligible for one-click donations (have saved their card information with us), and donors who have donated more than a certain amount in the last certain amount of days.

You can target activists based on source codes they've used to take action by filling in one or many source codes, separated by commas.

And you can target activists based on whether they've filled out a customfieldwith a certain name using a certain value. (ex: All activists who have the value of "yes" under the "unemployed" custom field.)You can also target based on core fields like email address or name, allowing you to target activists who have .edu in their email addresses for example.

% is the wildcard character for field targeting, so %.edu on the email field matches everyone who's email address ends in .edu. You can use multiple % characters, so %1% matches anyone who has a 1 in any part of the form field you're targeting.

You can also interpret custom fields as numbers or dates and target with greater than or less than operations using << or >>. For example, <<1 will target every activist with a custom field value numberless than 1. >>2017/12/01 14:00:15 will target everyone with a custom field value date after December 1st, 2017, 2:00pm and 15 seconds. The format for dates is yyyy/mm/dd hh:mm:ss. Time is optional.

You can also use regular expressions, so[0-9] will target any activistwith any of the characters 0-9 in that form field. The wildcard character can be combined with regular expressions. (For more detail on our regular expression parser and syntax, see .)

You can target activists based on tags they have on their record.

And you can target activists based on queries you've previously set up.

You can target activists based on whether they are targeted with a report you've previously made.

You can target activists based on their action activity level -- for example whether they've taken at least 3 actions in the last 90 days on your email list. This does not include uploads.

You can also target based on their email open or click activity level -- for example whether they've clicked at least 2 emails in the last 7 days. (If you're in a network, you can optionally include opens or clicks from child groups in this calculation as well, just select them from the dropdown menu.)

And you can target activists based on the date theysubscribed or resubscribedto your list-- for example subscribed 3 days ago or less.

Includes and Excludes

In standard mode, on the left side is your options for includes. Between each section is a logical AND operation and inside each section is a logical OR. (ex: If you select New York and Vermont from the State section and an action titled "Petition to Walmart" from the Action list, this email would target users who live in New York OR Vermont, AND have taken action on "Petition to Walmart.")

On the right side is your options for excludes. Between and inside each section is a logical OR operation. (ex: If you select New York and Vermont from the State section and an action titled "Petition to Walmart" from the Action list, this email would target all users on your list except those living in New York OR Vermont OR have taken action on "Petition to Walmart.")

You can use both includes and excludes at the same time. To do ANDs between a section, for example, you would target two emails by duplicating the first -- one targeted to the first group and one to the second. The lists of states, actions, emails, and reports are scrollable, and you can select more than one option by command-clicking each item on Mac or control-clicking on Windows.

In query mode, you get to choose the ANDs and ORs you want to use.

Saving and Re-Targeting

When you're ready, click "Save and Preview Send Your Email" to trigger the targeting process to calculate the number of people the email will be sent to, and to move on to the next step.

Your targeting will be calculated and saved. It will not update when the underlying data updates.

To do that, after you've saved your targeting once, if you come back to the targeting page you can update your targeting. Click the save and re-calculate button to re-run targeting and update it (including saving any changes in filter options you make). Otherwise, you can choose not to re-calculate, which can often save you time if your targeting or the underlying data has not really changed since the last time you saved.

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Never translate the destination address (also known as the target) in a link. The destination address is where a customer goes when they click the link. It's always shown in quotation marks and points to a specific web address.

HTML is sometimes used to give emphasis or additional styling to words or phrases, or to display symbols. You must translate only the words that are being styled by the HTML, and not the codes or tags themselves. Take a look at the Puma PHENOM LOW Sports shoes blue indigo/white 8M77SqX
to make sure that you understand what to translate and what you should leave unchanged.

In the following example, the <strong> tags are used to display text in bold:

In this case, you'd translate only the words On Sale .

On Sale

In the following example, HTML codes larr; and rarr; are used to generate left and right arrow symbols:

Here, you'd translate only the phrases Previous Product and Next Product .

Previous Product Next Product

In the following example, HTML <strong> tags are used to display the filename collection -sidebar.liquid in bold.

collection -sidebar.liquid

The filename here is a Liquid template file . You should translate the filename only if it's necessary to match the name of the file itself. For example, if you have created your own files, then you might need to change the filename in the HTML.

Never translate HTML tags or symbol codes. These are used by your browser, and are not seen by your customers.

Never translate Liquid tags, objects, or filters.

Liquid is the templating language that controls the appearance of your website in different contexts. Liquid content is always wrapped in one of the following sets of symbols:

For example:

In this example, you would translate only the text around the Liquid, and not {{ date }} .

Here's an example of a text field that uses a combination of plain text, HTML, and Liquid:

Although this example might look complex, the only part that you'd need to translate is the word on .

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, then you can continue to make changes.

To view or update a translation:

Add to the translations in the current language or click Change theme language to choose another language in the language editor .

View larger version:
Figure 4.

Each patient's at-risk time is dependent on when the patient began and ended CVC use during the study period.

Intravenous Antibiotic Analysis

An analysis was performed to investigate whether an increase in antibiotic use could be responsible for the decreased infection rates. The rate of intravenous (IV) antibiotic starts decreased by 0.6 per 1000 CVC-days from run-in period to intervention period, with the greatest decrease in the ClearGuard group. In addition, an analysis was performed to investigate whether there was a corresponding decrease in the rate of IV antibiotics associated with PBCs. The resulting IRR was 0.37 (<0.001) favoring ClearGuard ( Figure 3I , xkfVYhZDgu Princetown Leather Flat Mules cHikHHn
).

Other Analyses

Additional exploratory analyses were performed to observe trends in areas where the study was not designed to have sufficient power. CVC exchange rate was not statistically different in the ClearGuard group versus Tego+Curos (0.94 versus 1.03 per 1000 CVC-days, respectively; =0.8). CVC removal rate was similar between the two groups (7.57 versus 7.56 events per 1000 CVC-days, respectively; =0.9). Thrombolytic use rate was not significantly different between the two groups (1.84 versus 1.89 per 1000 CVC-days, respectively; =0.9). Hospital admissions for BSI were analyzed using the dialysis facilities’ records of admission (no other hospital records were available); the rate of hospitalizations for BSI was lower in the ClearGuard group versus Tego+Curos (0.06 versus 0.11 per 1000 CVC-days, respectively), but the difference was not statistically significant (IRR=0.55; =0.5). There were no deaths within 30 days of a PBC in the ClearGuard group, and three deaths in the Tego+Curos group; however, these results were statistically insignificant.

Lock solutions were not required to be reported. However, they were recorded in 33% of all procedures. Within both groups, the vast majority (>95%) of procedures used saline as the lock solution.

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This study demonstrated that use of ClearGuard resulted in a significantly lower BSI rate versus use of Tego+Curos.

During the 3-month run-in period, there was no statistical difference in PBC rates between the two groups. This suggests that groups were well balanced in terms of BSI risk and that differences in BSI rates seen during the intervention phase of the study can be more confidently ascribed to study interventions. The BSI rates were lower during intervention period versus run-in period in both groups, which is expected because ClearGuard and Curos are both designed to reduce BSI rates.

This study’s primary analysis, along with the exploratory analyses, demonstrated that in a real-world hemodialysis setting use of ClearGuard was superior to use of Tego+Curos at reducing PBCs, CRBSI, CLABSI, Gram-positive infections, Gram-negative infections, and IV antibiotic starts related to PBCs in patients undergoing hemodialysis using CVCs.

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